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InnoPran XL and Timothy grass pollen allergen extract Sublingual

Determining the interaction of InnoPran XL and Timothy grass pollen allergen extract Sublingual and the possibility of their joint administration.

Check result:
InnoPran XL <> Timothy grass pollen allergen extract Sublingual
Relevance: 11.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using timothy grass pollen allergen extract together with propranolol may not be advisable. Immunotherapy with timothy grass pollen allergen extract can sometimes cause severe, even potentially life-threatening allergic reactions that require emergency treatment with epinephrine and bronchodilators, and medications like propranolol can interfere with the body's response to these emergency treatments and significantly reduce their effectiveness. Talk to your doctor if you have any questions or concerns. Stop using timothy grass pollen allergen extract, administer epinephrine, and seek immediate medical attention if signs and symptoms of an allergic reaction develop such as trouble breathing, swallowing, or speaking; throat tightness or swelling; dizziness, lightheadedness, or fainting; rapid or weak heartbeat; severe stomach cramps or pain; vomiting or diarrhea; and/or severe flushing or itching. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Beta-blockers may attenuate the response to epinephrine and inhaled bronchodilators in the treatment of serious systemic reactions, including anaphylaxis, that may occur during immunotherapy with allergenic extracts. Noncardioselective beta-blockers, in particular, can antagonize the bronchodilating effects of beta-agonists by blocking beta-2 adrenergic receptors in smooth muscles of the bronchial tree, although cardioselective beta-blockers may occasionally do the same, as beta-1 selectivity is not absolute and may be lost at higher dosages in susceptible patients. All beta-blockers can antagonize the cardiostimulatory effects of beta-agonists by blocking beta-1 adrenergic receptors in the heart.

MANAGEMENT: Immunotherapy with allergenic extracts may not be appropriate in patients receiving beta-blockers, as these patients may be unresponsive to the usual doses of beta-agonists that may be required to reverse a systemic reaction. Canadian authorities consider the use of allergenic extracts to be contraindicated in patients on beta-blockers.

References
  • "Product Information. Oralair (mixed grass pollens allergen extract)." Greer Laboratories Inc, Lenoir, NC.
  • "Product Information. Ragwitek (ragweed pollen allergen extract)." Merck & Company Inc, Whitehouse Station, NJ.
  • "Product Information. Grastek (timothy grass pollen allergen extract)." Merck & Company Inc, Whitehouse Station, NJ.
InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

Timothy grass pollen allergen extract Sublingual

Generic Name: timothy grass pollen allergen extract

Brand name: Grastek

Synonyms: Timothy grass pollen allergen extract

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.