Inotersen and Nalbuphine Hydrochloride

• Generic Name: inotersen
• Dosage Forms: n.a.
• Other Brand Names: Tegsedi

Inotersen works by decreasing a protein called transthyretin (TTR, made primarily in the liver). Hereditary transthyretin-mediated amyloidosis (hATTR) is a rare condition in which abnormal deposits of TTR protein build up in many parts of the body, interfering with normal function.

Inotersen is used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hATTR. inotersen can help reduce symptoms such as pain, numbness, tingling, abnormal heartbeats, diarrhea, constipation, weakness, and problems with movement in your arms or legs.

Inotersen is available only from a certified pharmacy under a special program.

Inotersen may also be used for purposes not listed in this medication guide.

• Generic Name: nalbuphine
• Dosage Forms: n.a.
• Other Brand Names: Nubain

Relief of pain that is severe enough to require an opiate analgesic and for which alternative treatment options (e.g., nonopiate analgesics) have not been, or are not expected to be, adequate or tolerated.

Preoperative and postoperative sedation and analgesia.

Supplement to balanced surgical anesthesia.

Obstetric analgesia during labor and delivery.

In symptomatic treatment of acute pain, reserve opiate analgesics for pain resulting from severe injuries, severe medical conditions, or surgical procedures, or when nonopiate alternatives for relieving pain and restoring function are expected to be ineffective or are contraindicated. Use smallest effective dosage for shortest possible duration since long-term opiate use often begins with treatment of acute pain. Optimize concomitant use of other appropriate therapies. (See Managing Opiate Therapy for Acute Pain under Dosage and Administration.)