Inotersen Sodium and Promethazine Hydrochloride

• Generic Name: inotersen
• Dosage Forms: n.a.
• Other Brand Names: Tegsedi

Inotersen sodium is a transthyretin-directed antisense oligonucleotide indicated for treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.

• Generic Name: promethazine
• Dosage Forms: n.a.
• Other Brand Names: Phenergan, Phenadoz, Promethegan

Management of seasonal allergic rhinitis (e.g., hay fever) and perennial (nonseasonal) allergic rhinitis.

Management of seasonal nonallergic (vasomotor) rhinitis.

Symptomatic relief of rhinorrhea and sneezing associated with the common cold.

Adjunct to epinephrine and other standard measures in the treatment of anaphylactic reactions after the acute manifestations have been controlled.

Used IM for management of other uncomplicated allergic reactions of the immediate type when oral therapy is impossible or contraindicated.

Prevention and treatment of mild, uncomplicated skin manifestations of urticaria and angioedema.

Management of allergic conjunctivitis caused by foods or inhaled allergens.

Treatment of mild transfusion reactions not caused by ABO incompatibility or pyrogens.

Treatment of dermatographism.

Treatment to produce sedation in surgery and obstetrics (during labor); reduces preoperative tension and anxiety, facilitates sleep.

Routine sedation.

Adjunct to analgesics (e.g., opiates) for management of pain (e.g., postoperative).

Used IV as adjunct to analgesics (e.g., opiates) and anesthesia during surgery (e.g., bronchoscopy, ophthalmic surgery) and in poor-risk patients.

Prevention and treatment of nausea, vomiting, and/or vertigo associated with motion sickness.

Prevention and management of nausea and vomiting of various etiologies (e.g., anesthesia, surgery, postoperative).

May ameliorate hemolytic disease of the newborn (erythroblastosis fetalis) when administered during pregnancy in Rh-sensitized women.