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Inrebic and Sarafem

Determining the interaction of Inrebic and Sarafem and the possibility of their joint administration.

Check result:

Inrebic <> Sarafem

Relevance: 10.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with dual CYP450 3A4 and 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of these isoenzymes. However, clinical data evaluating the interaction are not available. MANAGEMENT: According to the product labeling, concomitant use of fedratinib with dual CYP450 3A4 and 2C19 inhibitors should be avoided. References "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.

Professional:

GENERALLY AVOID: Coadministration with dual CYP450 3A4 and 2C19 inhibitors may increase the plasma concentrations of fedratinib, which is a substrate of these isoenzymes. However, clinical data evaluating the interaction are not available.

MANAGEMENT: According to the product labeling, concomitant use of fedratinib with dual CYP450 3A4 and 2C19 inhibitors should be avoided.

References

"Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.

Inrebic

Generic Name: fedratinib

Brand name: Inrebic

Synonyms: n.a.

What is Inrebic?

Sarafem

Generic Name: fluoxetine

Brand name: Prozac, Prozac Weekly, Sarafem, PROzac Pulvules, Rapiflux, Selfemra

Synonyms: n.a.

What is Sarafem?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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