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Inspra and Lithium Syrup and Oral Solution

Determining the interaction of Inspra and Lithium Syrup and Oral Solution and the possibility of their joint administration.

Check result:

Inspra <> Lithium Syrup and Oral Solution

Relevance: 17.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lithium together with eplerenone may increase the effects of lithium. Contact your doctor if you experience drowsiness, dizziness, confusion, weakness, tremor, visual disturbances, thirst, or increased urination. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Theoretically, coadministration with eplerenone may increase the serum concentrations and pharmacologic effects of lithium. Although the interaction has not specifically been studied with eplerenone, it has been reported with other drugs that suppress or antagonize aldosterone such as ACE inhibitors, angiotensin II receptor antagonists, and spironolactone. The exact mechanism of interaction is unknown but may involve enhanced reabsorption of lithium from renal tubules secondary to the natriuresis produced by these drugs.

MANAGEMENT: Caution is advised if eplerenone must be used concomitantly with lithium. Pharmacologic response and serum lithium levels should be monitored closely and the dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of eplerenone in patients who are stabilized on their lithium regimen. Patients should be advised to notify their physician if they experience early symptoms of lithium toxicity such as drowsiness, dizziness, diarrhea, vomiting, muscle weakness, incoordination, ataxia, tremor, blurred vision, tinnitus, excessive thirst, or increased urination.

References

Baer L, Platman SR, Kassir S, Fieve RR "Mechanisms of renal lithium handling and their relationship to mineralocorticoids: a dissociation between sodium and lithium ions." J Psychiatr Res 8 (1971): 91-105
Griffin JH, Hahn SM "Lisinopril-induced lithium toxicity." Drug Intell Clin Pharm 25 (1991): 101
Douste-Blazy P, Rostin M, Livarek B, et al "Angiotensin converting enzyme inhibitors and lithium treatment." Lancet 1 (1986): 1448
Blanche P, Raynaud E, Kerob D, Galezowski N "Lithium intoxication in an elderly patient after combined treatment with losartan." Eur J Clin Pharmacol 52 (1997): 501
Correa FJ, Eiser AR "Angiotensin-converting enzyme inhibitors and lithium toxicity." Am J Med 93 (1992): 108-9
Gillman MA, Lichtigfeld FJ "Synergism of spironolactone and lithium in mania." Br Med J 292 (1986): 661-2
Leung M, Remick RA "Potential drug interaction between lithium and valsartan." J Clin Psychopharmacol 20 (2000): 392-3
Baldwin CM, Safferman AZ "A case of lisinopril-induced lithium toxicity." DICP 24 (1990): 946-7
"Product Information. Inspra (eplerenone)." Searle, Chicago, IL.
Finley PR, Obrien JG, Coleman RW "Lithium and angiotensin-converting enzyme inhibitors: evaluation of a potential interaction." J Clin Psychopharmacol 16 (1996): 68-71

Inspra

Generic Name: eplerenone

Brand name: Inspra

Synonyms: n.a.

What is Inspra?

Lithium Syrup and Oral Solution

Generic Name: lithium

Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR

Synonyms: Lithium

What is Lithium Syrup and Oral Solution?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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