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Insulin degludec and liraglutide and Metamucil (Psyllium Powder)

Determining the interaction of Insulin degludec and liraglutide and Metamucil (Psyllium Powder) and the possibility of their joint administration.

Check result:

Insulin degludec and liraglutide <> Metamucil (Psyllium Powder)

Relevance: 24.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using liraglutide together with insulin degludec can increase the risk of hypoglycemia, or low blood sugar. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. Let your doctor know if you experience hypoglycemia during treatment. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Coadministration of a glucagon-like peptide-1 (GLP-1) receptor agonist with insulin may potentiate the risk of hypoglycemia. GLP-1 receptor agonists lower blood glucose by stimulating insulin secretion and lowering glucagon secretion.

MANAGEMENT: When a GLP-1 receptor agonist is used as add-on therapy to basal insulin, a lower dosage of insulin may be required. Blood glucose should be monitored closely, and patients should be counseled to recognize the symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia. If hypoglycemia occurs, patients should initiate appropriate remedial therapy immediately and contact their physician. Patients should also be advised to take precautions to avoid hypoglycemia while driving or operating hazardous machinery. Concurrent use of GLP-1 receptor agonists with prandial insulin has not been studied and is generally not recommended.

References

"Product Information. Ozempic (1 mg dose) (semaglutide)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
"Product Information. Adlyxin (lixisenatide)." sanofi-aventis, Bridgewater, NJ.
"Product Information. Trulicity (dulaglutide)." Eli Lilly and Company, Indianapolis, IN.
"Product Information. Victoza (liraglutide)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
"Product Information. Tanzeum (albiglutide)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Byetta (exenatide)." Amylin Pharmaceuticals Inc, San Diego, CA.

Insulin degludec and liraglutide

Generic Name: insulin degludec / liraglutide

Brand name: Xultophy

Synonyms: Insulin Degludec and Liraglutide

What is Insulin degludec and liraglutide?

Metamucil (Psyllium Powder)

Generic Name: psyllium

Brand name: Hydrocil, Konsyl, Laxmar, Metamucil, Natural Fiber Therapy, Reguloid, Fiberall, Syllact, Modane Bulk, V-Lax, Perdiem Fiber Powder, Konsyl-Orange, Konsyl-D, Maalox Daily Fiber Therapy, Cilium, Alramucil, Serutan, Laxative Natural, Genfiber, Fiber Eze, Konsyl for Kids, Laxmar Orange, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Unflavored Coarse Milled Original, Fiber Therapy, Metamucil Orange Coarse Milled Original, Metamucil Unflavored Smooth Texture, Metamucil Berry Burst Smooth Texture, Laxmar Sugar Free, Konsyl Orange Sugar-free, Metamucil Pink Lemonade Smooth Texture Sugar-Free, Metamucil Original Texture Regular, Metamucil MultiHealth Fiber, Metamucil MultiHealth Fiber Sugar-free, Reguloid Sugar Free, Reguloid Orange Smooth, Reguloid Sugar Free Orange Smooth, Konsyl Sugar Free Orange With Stevia

Synonyms: Metamucil

What is Metamucil (Psyllium Powder)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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