Insulin Degludec (U-100) Prefilled Pens and Phentolamine Mesylate
Determining the interaction of Insulin Degludec (U-100) Prefilled Pens and Phentolamine Mesylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Phentolamine can increase the endogenous secretion of insulin in patients with type II diabetes mellitus. Theoretically, this effect could decrease insulin requirements. However, since phentolamine is usually administered only in single doses, the clinical importance is probably limited. Management consists of carefully monitoring blood glucose after the administration of phentolamine if the situation warrants.
- Linde J, Deckert T "Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion." Horm Metab Res 5 (1973): 391-5
- Persson I, Larsen L "Serum insulin concentration after alpha-adrenergic blockade and secretin in diabetics." Acta Endocrinol (Copenh) 71 (1972): 331-7
Generic Name: insulin degludec
Brand name: Tresiba, Tresiba FlexTouch
Synonyms: Insulin degludec, Insulin Degludec
Generic Name: phentolamine
Brand name: OraVerse
Synonyms: Phentolamine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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