Drug search by name

Insulin human inhaled Inhalation and Zilretta

Determining the interaction of Insulin human inhaled Inhalation and Zilretta and the possibility of their joint administration.

Check result:

Insulin human inhaled Inhalation <> Zilretta

Relevance: 24.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Use of other orally inhaled products can sometimes affect the absorption of inhaled insulin into the bloodstream. In addition, medications like triamcinolone can increase blood sugar and worsen diabetes in some people. If you use inhaled insulin with other orally inhaled medications, you should keep the timing of their dosing consistent relative to each other on a daily basis and monitor your blood glucose closely. Talk to your doctor or pharmacist if you have any questions on how to use these medications properly. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Bronchodilators and other orally inhaled products may alter the absorption of inhaled human insulin. In nondiabetic subjects with mild asthma (n=36) and moderate asthma (n=31), administration of albuterol 30 minutes prior to inhaled human insulin resulted in a mean increase in insulin systemic exposure (AUC) and peak plasma concentration (Cmax) of 25% to 50% compared to administration of inhaled human insulin alone.

MONITOR: Systemic administration or systemic absorption of orally inhaled corticosteroids and sympathomimetic amines (bronchodilators) may result in diminished efficacy of insulin. These drugs may interfere with blood glucose control because they can cause hyperglycemia, glucose intolerance, new-onset diabetes mellitus, and/or exacerbation of preexisting diabetes.

MANAGEMENT: Consistent timing of dosing of other inhaled products relative to inhaled human insulin administration is recommended. Blood glucose should be monitored closely, and the insulin dose adjusted accordingly.

References

Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4
Ludvik B, Clodi M, Kautzky-Willer A, Capek M, Hartter E, Pacini G, Prager R "Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans." Diabetologia 36 (1993): 84-7
"Product Information. EXUBERA (insulin inhalation, rapid acting)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Gunnarsson R, Lundgren G, Magnusson G, Ost L, Groth CG "Steroid diabetes--a sign of overtreatment with steroids in the renal graft recipient?" Scand J Urol Nephrol Suppl 54 (1980): 135-8
Black DM, Filak AT "Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection." J Fam Pract 28 (1989): 462-3

Insulin human inhaled Inhalation

Generic Name: insulin inhalation, rapid acting

Brand name: Afrezza, Exubera, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, Afrezza 4 unit- 8 unit, Afrezza 8 unit- 12 unit, Afrezza Titration Pack, Exubera

Synonyms: Insulin (inhalation), Insulin (Oral Inhalation)

What is Insulin human inhaled Inhalation?

Zilretta

Generic Name: triamcinolone

Brand name: Kenalog-40, Zilretta, Aristocort, Azmacort

Synonyms: Zilretta (injection)

What is Zilretta?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions