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Insulin Regular (U-100) Vials and Monodox

Determining the interaction of Insulin Regular (U-100) Vials and Monodox and the possibility of their joint administration.

Check result:

Insulin Regular (U-100) Vials <> Monodox

Relevance: 21.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using doxycycline together with insulin or certain other diabetes medications may increase the risk of hypoglycemia, or low blood sugar. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Tetracyclines may enhance the hypoglycemic effect of insulin by increasing tissue sensitivity to exogenous insulin.

MANAGEMENT: Blood glucose should be monitored closely whenever tetracyclines are prescribed to patients on insulin, especially if they are elderly or have renal impairment. The insulin dosage may require adjustment if an interaction is suspected. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations), how to treat it, and to contact their physician if it occurs.

References

Phillips PJ, Easterbrook G "Phenformin, tetracycline and lactic acidosis." Ann Intern Med 86 (1977): 111
Dalpe-Scott M, Heick HM, Begin-Heick N "Insulin secretion in the obese (ob/ob) mouse: the effect of oxytetracycline on insulin release." Diabetes 32 (1983): 932-7
Hiatt N, Bonorris G "Insulin response in pancreatectomized dogs treated with oxytetracycline." Diabetes 19 (1970): 307-11
Dalpe-Scott M, Begin-Heick N "Oxytetracycline treatment improves the response to insulin in the spontaneously diabetic (BB) rat." Diabetes 31 (1982): 53-9
Miller JB "Hypoglycaemic effect of oxytetracycline." BMJ 2 (1966): 1007
Begin-Heick N, Heick HM, Norman MG "Regranulation of Islets of Langerhans and normalization of in vivo insulin secretion in ob/ob mice treated with oxytetracycline." Diabetes 28 (1979): 65-70

Insulin Regular (U-100) Vials

Generic Name: insulin regular

Brand name: Humulin R, Myxredlin, Novolin R, HumuLIN R KwikPen

Synonyms: Insulin Regular

What is Insulin Regular (U-100) Vials?

Monodox

Generic Name: doxycycline

Brand name: Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Vibramycin, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX

Synonyms: n.a.

What is Monodox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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