Intelence and Isavuconazonium Sulfate Injection
Determining the interaction of Intelence and Isavuconazonium Sulfate Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using isavuconazonium together with etravirine can alter the blood levels and effects of both medications. Specifically, isavuconazonium levels may decrease, which may make the medication less effective. At the same time, etravirine levels may increase. Contact your doctor if your condition changes or you experience increased side effects. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of etravirine with a drug, such as isavuconazonium sulfate (prodrug of isavuconazole), that is both a substrate as well as inhibitor of CYP450 3A4 may result in increased plasma concentrations of etravirine and decreased plasma concentrations of isavuconazole. Etravirine itself is a substrate and inducer of CYP450 3A4. Theoretically, etravirine may induce metabolism of isavuconazole while its own metabolism may be inhibited by the isavuconazole.
MANAGEMENT: Because safety data regarding increased etravirine exposures are limited, caution is advised if etravirine is prescribed in combination with isavuconazonium sulfate. In addition, the potential for decreased efficacy of isavuconazole should be considered. Dosage adjustments may be required for one or both drugs.
- "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium, Isavuconazonium Sulfate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Intelence-Isentress
- Intelence-Isentress (Raltegravir Chewable Tablets)
- Intelence-Isentress (Raltegravir Powder for Oral Suspension)
- Intelence-Isentress (Raltegravir Tablets)
- Intelence-Isentress HD
- Intelence-Isibloom
- Isavuconazonium Sulfate Injection-Interferon alfa-2b
- Isavuconazonium Sulfate Injection-Interferon alfa-2b Injection
- Isavuconazonium Sulfate Injection-Interferon Alfa-2b Injection Solution
- Isavuconazonium Sulfate Injection-Interferon Alfa-2b Powder for Injection
- Isavuconazonium Sulfate Injection-Interferon Alfa-2b Prefilled Pens
- Isavuconazonium Sulfate Injection-Interferon alfa-n3