Intelence and Lamivudine and Tenofovir Disoproxil Fumarate
Determining the interaction of Intelence and Lamivudine and Tenofovir Disoproxil Fumarate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with tenofovir may reduce the plasma concentrations of etravirine. The mechanism of interaction has not been described. In 23 study subjects administered etravirine with tenofovir disoproxil fumarate 300 mg once a day, etravirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by nearly 20% each. These changes were statistically, but not clinically, significant. Etravirine had no effect on the pharmacokinetics of tenofovir. Etravirine and tenofovir disoproxil fumarate may be coadministered without any dosage adjustments.
- "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: lamivudine / tenofovir
Brand name: Cimduo, Temixys
Synonyms: Lamivudine and tenofovir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Intelence-Lamivudine and zidovudine
- Intelence-Lamivudine and Zidovudine Tablets
- Intelence-Lamivudine Oral Solution
- Intelence-Lamivudine Tablets
- Intelence-Lamotrigine
- Intelence-Lamotrigine Chewable Dispersible Tablets
- Lamivudine and Tenofovir Disoproxil Fumarate-Interferon alfa-2b
- Lamivudine and Tenofovir Disoproxil Fumarate-Interferon alfa-2b Injection
- Lamivudine and Tenofovir Disoproxil Fumarate-Interferon Alfa-2b Injection Solution
- Lamivudine and Tenofovir Disoproxil Fumarate-Interferon Alfa-2b Powder for Injection
- Lamivudine and Tenofovir Disoproxil Fumarate-Interferon Alfa-2b Prefilled Pens
- Lamivudine and Tenofovir Disoproxil Fumarate-Interferon alfa-n3