About us Contacts Drug interactions: 390 212
Drug search by name

Intelence and Lidocaine Hydrochloride (Local)

Determining the interaction of Intelence and Lidocaine Hydrochloride (Local) and the possibility of their joint administration.

Check result:
Intelence <> Lidocaine Hydrochloride (Local)
Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using etravirine together with lidocaine may decrease the effects of lidocaine. Contact your doctor if your condition changes or if you experience a worsening of heart symptoms If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with etravirine may decrease the plasma concentrations of certain antiarrhythmic agents. The proposed mechanism is etravirine induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of antiarrhythmics such as amiodarone, bepridil, disopyramide, lidocaine, and quinidine.

MANAGEMENT: Caution is advised if etravirine is prescribed to patients receiving antiarrhythmic agents. Drug concentration monitoring is recommended, if available.

References
  • "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Intelence

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

Lidocaine Hydrochloride (Local)

Generic Name: lidocaine

Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine

Synonyms: Lidocaine injection, Lidocaine (Systemic)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle