Intelence and Methadone HCl Intensol
Determining the interaction of Intelence and Methadone HCl Intensol and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using etravirine together with methadone may decrease the effects of methadone. Contact your doctor if your condition changes or if you experience restlessness, insomnia, sweating, increased tear production, or a runny nose. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with etravirine may theoretically decrease the plasma concentrations of methadone. The proposed mechanism is etravirine induction of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of methadone. No significant effect of etravirine on methadone pharmacokinetics was observed in 16 study subjects receiving methadone maintenance ranging from 60 to 130 mg/day. However, an interaction may occur in susceptible patients.
MANAGEMENT: Etravirine product labeling recommends clinical monitoring for withdrawal symptoms in patients receiving methadone maintenance therapy, and the methadone dosage adjusted as necessary.
- "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: methadone
Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets
Synonyms: Methadone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Intelence-Methadone Hydrochloride
- Intelence-Methadone Injection
- Intelence-Methadone Injection Solution
- Intelence-Methadone Oral Concentrate
- Intelence-Methadone Oral Solution
- Intelence-Methadone Powder
- Methadone HCl Intensol-Interferon alfa-2b
- Methadone HCl Intensol-Interferon alfa-2b Injection
- Methadone HCl Intensol-Interferon Alfa-2b Injection Solution
- Methadone HCl Intensol-Interferon Alfa-2b Powder for Injection
- Methadone HCl Intensol-Interferon Alfa-2b Prefilled Pens
- Methadone HCl Intensol-Interferon alfa-n3