Intelence and Omeprazole and Sodium Bicarbonate Capsule
Determining the interaction of Intelence and Omeprazole and Sodium Bicarbonate Capsule and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using etravirine together with omeprazole may alter the blood levels and effects of both medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of etravirine with a drug that is both a substrate as well as inhibitor of CYP450 2C19 and/or 2C9 may result in increased plasma concentrations of both drugs. Etravirine itself is also a substrate and inhibitor of CYP450 2C19 and 2C9. Theoretically, metabolism of etravirine and the coadministered drug may be mutually inhibited when used in combination. In 18 study subjects administered etravirine with the CYP450 2C19 inhibitor omeprazole (40 mg once a day), etravirine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 17% and 41%, respectively. The effect of etravirine on omeprazole pharmacokinetics was not reported.
MANAGEMENT: Because safety data regarding increased etravirine exposures are limited, caution is advised if etravirine is prescribed in combination with a CYP450 2C19 or 2C9 inhibitor. In addition, dosage adjustments may be required for the coadministered drug if it is also a substrate of CYP450 2C19 or 2C9.
- "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: omeprazole / sodium bicarbonate
Brand name: Zegerid, Zegerid OTC
Synonyms: Omeprazole and sodium bicarbonate, Omeprazole and Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Intelence-Omeprazole and Sodium Bicarbonate Capsules
- Intelence-Omeprazole and Sodium Bicarbonate Powder Packets
- Intelence-Omeprazole Delayed-Release Capsules
- Intelence-Omeprazole Delayed-Release Capsules and Tablets (OTC)
- Intelence-Omeprazole Orally-Disintegrating Tablets
- Intelence-Omeprazole Powder for Oral Suspension
- Omeprazole and Sodium Bicarbonate Capsule-Interferon alfa-2b
- Omeprazole and Sodium Bicarbonate Capsule-Interferon alfa-2b Injection
- Omeprazole and Sodium Bicarbonate Capsule-Interferon Alfa-2b Injection Solution
- Omeprazole and Sodium Bicarbonate Capsule-Interferon Alfa-2b Powder for Injection
- Omeprazole and Sodium Bicarbonate Capsule-Interferon Alfa-2b Prefilled Pens
- Omeprazole and Sodium Bicarbonate Capsule-Interferon alfa-n3