Intelence and Paclitaxel protein-bound Intravenous
Determining the interaction of Intelence and Paclitaxel protein-bound Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Etravirine may reduce the blood levels and effects of PACLitaxel protein-bound. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with etravirine may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is accelerated clearance due to induction of CYP450 3A4 activity by etravirine. In 15 study subjects coadministered etravirine and the CYP450 3A4 substrate sildenafil (50 mg single dose), sildenafil peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 45% and 57%, respectively, while Cmax and AUC of its active N-desmethyl metabolite decreased by 25% and 41%, respectively.
MANAGEMENT: Caution is advised if etravirine must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever etravirine is added to or withdrawn from therapy.
- "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: paclitaxel protein-bound
Brand name: Abraxane
Synonyms: Paclitaxel protein-bound, PACLitaxel (Protein Bound)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Intelence-Pacnex
- Intelence-Pacnex LP
- Intelence-Pacnex MX
- Intelence-Pain Enz Topical
- Intelence-Pain Relief PM Extra Strength
- Intelence-Pain Reliever Plus
- Paclitaxel protein-bound Intravenous-Interferon alfa-2b
- Paclitaxel protein-bound Intravenous-Interferon alfa-2b Injection
- Paclitaxel protein-bound Intravenous-Interferon Alfa-2b Injection Solution
- Paclitaxel protein-bound Intravenous-Interferon Alfa-2b Powder for Injection
- Paclitaxel protein-bound Intravenous-Interferon Alfa-2b Prefilled Pens
- Paclitaxel protein-bound Intravenous-Interferon alfa-n3