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Intelence and Reyataz (Atazanavir Powder for Oral Suspension)

Determining the interaction of Intelence and Reyataz (Atazanavir Powder for Oral Suspension) and the possibility of their joint administration.

Check result:

Intelence <> Reyataz (Atazanavir Powder for Oral Suspension)

Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Etravirine may reduce the blood levels of atazanavir, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with etravirine may decrease the plasma concentrations of atazanavir, with or without cobicistat or low-dose ritonavir as a pharmacokinetic booster. The plasma concentrations of cobicistat may also be reduced. The mechanism is etravirine induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of atazanavir, other protease inhibitors, and cobicistat. In 14 study subjects administered atazanavir 400 mg once a day with etravirine, atazanavir trough plasma concentration (Cmin) decreased significantly by approximately 47%. In 20 HIV-infected patients administered atazanavir-ritonavir (300 mg/100 mg) once a day with etravirine, the atazanavir Cmin decreased by 18%; this reduction is not considered clinically relevant. In contrast, etravirine plasma concentration is increased by the protease inhibitors, presumably due to inhibition of CYP450 3A4. Both etravirine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 50% during coadministration with atazanavir and 30% during coadministration with atazanavir-ritonavir, while etravirine Cmin increased by 58% and 26%, respectively. The systemic exposure of etravirine during coadministration with atazanavir-ritonavir was similar to exposures of etravirine observed during Phase 3 trials, where all subjects received darunavir-ritonavir as part of the background regimen.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, neither unboosted atazanavir nor atazanavir boosted with cobicistat should be prescribed in combination with etravirine. According to the product labeling for etravirine, atazanavir boosted with ritonavir may be given concomitantly with etravirine in treatment-experienced patients without dose adjustments.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Department of Health and Human Services "Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Available from: URL: https://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultAndAdolescentGL.pdf." ([2015, April 8]):

Intelence

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Intelence?

Reyataz (Atazanavir Powder for Oral Suspension)

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Reyataz

What is Reyataz (Atazanavir Powder for Oral Suspension)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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