Intelence and Tenofovir Disoproxil Fumarate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with tenofovir may reduce the plasma concentrations of etravirine. The mechanism of interaction has not been described. In 23 study subjects administered etravirine with tenofovir disoproxil fumarate 300 mg once a day, etravirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by nearly 20% each. These changes were statistically, but not clinically, significant. Etravirine had no effect on the pharmacokinetics of tenofovir. Etravirine and tenofovir disoproxil fumarate may be coadministered without any dosage adjustments.

Intelence

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Intelence?

Tenofovir Disoproxil Fumarate

Generic Name: tenofovir

Brand name: Vemlidy, Viread

Synonyms: Tenofovir

What is Tenofovir Disoproxil Fumarate?