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Intuniv and Silenor

Determining the interaction of Intuniv and Silenor and the possibility of their joint administration.

Check result:

Intuniv <> Silenor

Relevance: 24.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using doxepin together with guanFACINE can decrease the effects of guanFACINE. Talk with your doctor before using doxepin and guanFACINE together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: One case report suggests that tricyclic antidepressants may decrease the antihypertensive effect of guanfacine. The mechanism is unknown.

MANAGEMENT: The patient's blood pressure should be monitored during concomitant therapy and after discontinuation or dose change of the antidepressant. An alternative antihypertensive (e.g., beta adrenergic blocking agent, diuretic) may be considered.

References

Buckley M, Feely J "Antagonism of antihypertensive effect of guanfacine by tricyclic antidepressants." Lancet 337 (1991): 1173-4

Intuniv

Generic Name: guanfacine

Brand name: Intuniv, Tenex

Synonyms: n.a.

What is Intuniv?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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