Iobenguane I-123 and Sudafed PE Pressure+Pain+Cold

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Phenylephrine may interfere with imaging studies done with iobenguane I-123. Let your doctor know you are receiving or have recently received phenylephrine if you are scheduled for an imaging procedure to detect pheochromocytoma or neuroblastoma (tumors in the nervous system). You may need to stop using phenylephrine for a certain amount of time before having the procedure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with drugs that block norepinephrine uptake or deplete norepinephrine stores may decrease iobenguane I-123 uptake in neuroendocrine tumors and lead to false-negative imaging results. Since iobenguane I-123 is subject to the same uptake and accumulation pathways as norepinephrine, drugs that alter norepinephrine disposition in adrenergic nerve terminals and presynaptic storage vesicles will likewise affect iobenguane. These drugs include antihypertensive agents that deplete norepinephrine stores or inhibit reuptake (e.g., guanethidine, reserpine, labetalol); antidepressants that inhibit norepinephrine transporter function (e.g., tricyclic antidepressants, selective serotonin reuptake inhibitors); sympathomimetic amines (e.g., phenylephrine, phenylpropanolamine, pseudoephedrine, ephedrine); central nervous stimulants (e.g., amphetamines); phenothiazines; and cocaine. Clinical studies have not determined which specific drugs may cause false-negative imaging results and whether all drugs in a specific pharmacologic class have the same potential to produce negative imaging results. Increasing the dose of iobenguane I-123 will not overcome any potential effect of these drugs.

MANAGEMENT: When medically feasible, any drug that blocks norepinephrine uptake or deplete norepinephrine stores should be discontinued for at least five biological half-lives before iobenguane I-123 administration. Patients should be monitored for the occurrence of clinically significant withdrawal symptoms, especially patients with elevated levels of circulating catecholamines and their metabolites.

Iobenguane I-123

Generic Name: iobenguane I 123

Brand name: AdreView

Synonyms: I-123 MIBG

What is Iobenguane I-123?

Sudafed PE Pressure+Pain+Cold

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: Decorel Forte Plus Cold/Cough, Mucinex Fast-Max, Mucinex Fast-Max Cold and Flu, Mucinex Fast-Max Congestion and Cold, Mucinex Fast-Max Severe Cold, Tylenol Cold Multi-Symptom Severe Daytime, Tylenol Cold Head Congestion Severe, Non-Pseudo Cold Relief, Phenflu DM, Sudafed PE Cold & Cough, Cold & Cough PE, Cold Head Congestion Severe Daytime, Cold Multi-Symptom Severe Daytime Cool Ice, Tylenol Cold & Flu Severe, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Severe Congestion & Cold, Cough & Sore Throat, DayQuil Severe Cold & Flu, Adult Cold, Cold & Flu Severe, Mucinex Sinus-Max Severe Congestion Relief, Delsym Cough + Cold Daytime, Severe Day Time Cold & Flu, Mucinex Fast-Max Cold & Flu, Mucinex Sinus-Max Pressure, Pain & Cough

Synonyms: n.a.

What is Sudafed PE Pressure+Pain+Cold?