Irbesartan and Hydrochlorothiazide and Methylprednisolone
Determining the interaction of Irbesartan and Hydrochlorothiazide and Methylprednisolone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using methylPREDNISolone, tell your doctor if you also use hydroCHLOROthiazide. You may need a dose adjustment or special tests in order to safely take both medications together. This combination may cause muscle pains or cramps, loss of appetite, weakness, dizziness, or confusion. If you take both medications together, tell your doctor if you have any of these symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant use of corticosteroids and agents that deplete potassium (e.g., potassium-wasting diuretics, amphotericin B, cation exchange resins) may result in increased risk of hypokalemia. Corticosteroids can produce hypokalemia and other electrolyte disturbances via mineralocorticoid effects, the degree of which varies with the agent (from most to least potent: fludrocortisone - cortisone/hydrocortisone - prednisolone/prednisone - other glucocorticoids) and route of administration (i.e. systemic vs. local). However, large systemic doses of any corticosteroid can demonstrate these effects, particularly if given for longer than brief periods. When used pharmacologically, adrenocorticotropic agents such as corticotropin have similar mineralocorticoid activities as cortisone and hydrocortisone.
MANAGEMENT: Patients receiving potassium-depleting agents with corticosteroids should be monitored closely for development of hypokalemia, particularly if fludrocortisone or large doses of another corticosteroid or adrenocorticotropic agent is given. Potassium supplementation may be necessary. Patients should be advised to notify their physician if they experience signs of electrolyte disturbances such as weakness, lethargy, and muscle pains or cramps.
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Generic Name: hydrochlorothiazide / irbesartan
Brand name: Avalide
Synonyms: Hydrochlorothiazide and irbesartan
Generic Name: methylprednisolone
Brand name: Medrol, Medrol Dosepak, MethylPREDNISolone Dose Pack, A-methapred, Depo-Medrol, Solu-Medrol
Synonyms: MethylPREDNISolone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Irbesartan and Hydrochlorothiazide-Methylprednisolone Acetate
- Irbesartan and Hydrochlorothiazide-MethylPREDNISolone Dose Pack
- Irbesartan and Hydrochlorothiazide-Methylprednisolone injection
- Irbesartan and Hydrochlorothiazide-Methylprednisolone Sodium Succinate
- Irbesartan and Hydrochlorothiazide-Methylprednisolone Sodium Succinate Injection
- Irbesartan and Hydrochlorothiazide-Methylprednisolone Tablets
- Methylprednisolone-Ircon
- Methylprednisolone-Irenka
- Methylprednisolone-Iressa
- Methylprednisolone-Iressa Oral
- Methylprednisolone-Irinotecan
- Methylprednisolone-Irinotecan (Conventional)