Isavuconazonium and Sitagliptin and metformin
Determining the interaction of Isavuconazonium and Sitagliptin and metformin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Isavuconazonium may increase the blood levels and effects of metFORMIN. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with isavuconazonium sulfate (prodrug of isavuconazole) may increase the plasma concentration and effects of metformin. The proposed mechanism is inhibition of organic cation transporter 2 (OCT2)-mediated elimination by isavuconazole. Coadministration of isavuconazole sulfate with metformin increased metformin AUC by 52% and Cmax by 23%.
MANAGEMENT: Caution is advised if isavuconazonium sulfate (prodrug of isavuconazole) is used concomitantly with metformin. Dose adjustments of metformin as well as clinical and laboratory monitoring of glycemic control may be appropriate whenever isavuconazole sulfate is added to or withdrawn from therapy. Patients should be advised to be alert to potential signs and symptoms of hypoglycemia such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitations, and tachycardia.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium Sulfate
Generic Name: metformin / sitagliptin
Brand name: Janumet, Janumet XR
Synonyms: Metformin and sitagliptin, Sitagliptin and Metformin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Isavuconazonium-Sitagliptin and Metformin Extended-Release Tablets
- Isavuconazonium-Sitagliptin and Metformin Tablets
- Isavuconazonium-Sitagliptin and simvastatin
- Isavuconazonium-Sitagliptin Phosphate
- Isavuconazonium-Sitavig
- Isavuconazonium-Sivextro
- Sitagliptin and metformin-Isavuconazonium Intravenous
- Sitagliptin and metformin-Isavuconazonium Sulfate
- Sitagliptin and metformin-Isavuconazonium Sulfate Capsules
- Sitagliptin and metformin-Isavuconazonium Sulfate Injection
- Sitagliptin and metformin-Isentress
- Sitagliptin and metformin-Isentress (Raltegravir Chewable Tablets)