Isavuconazonium Intravenous and Nafcillin Sodium
Determining the interaction of Isavuconazonium Intravenous and Nafcillin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nafcillin may reduce the blood levels of isavuconazonium. In some cases, this may make the medication less effective. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of isavuconazole, which is primarily metabolized by CYP450 3A4 and 3A5 and subsequently by uridine diphosphate glucuronosyltransferases (UGT). When multiple doses of isavuconazonium sulfate (prodrug of isavuconazole) were administered to healthy volunteers with multiple doses of the potent CYP450 3A4 inducer rifampin (600 mg), mean isavuconazole peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 75% and 97%, respectively. The extent to which other, less potent inducers of CYP450 3A4 may interact with isavuconazole is unknown.
MANAGEMENT: Caution is advised during concomitant use of isavuconazonium sulfate with CYP450 3A4 inducers. The potential for decreased efficacy of isavuconazonium sulfate should be considered.
- "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc, Deerfield, IL.
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium, Isavuconazonium Sulfate
Generic Name: nafcillin
Brand name: Unipen, Nallpen
Synonyms: Nafcillin (injection), Nafcillin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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