Isavuconazonium Intravenous and Posaconazole oral/injection
Determining the interaction of Isavuconazonium Intravenous and Posaconazole oral/injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using isavuconazonium together with posaconazole is not recommended. Combining these medications may significantly increase the blood levels of isavuconazole, the active component of isavuconazonium. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, and liver problems. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of isavuconazole, which is primarily metabolized by CYP450 3A4 and 3A5 and subsequently by uridine diphosphate glucuronosyltransferases (UGT). When a single dose of isavuconazonium sulfate (equivalent to 200 mg of isavuconazole) was administered to healthy volunteers following multiple dosing of the potent CYP450 3A4 inhibitor ketoconazole (200 mg twice daily for 24 days), isavuconazole peak plasma concentration (Cmax) increased by 9% and systemic exposure (AUC) increased by 422%.
MANAGEMENT: Concomitant use of isavuconazonium sulfate with potent CYP450 3A4 inhibitors is considered contraindicated. Ritonavir given at low dosages as a pharmacokinetic booster may be used with caution, but is contraindicated at high dosages (e.g., 400 mg every 12 hours).
- "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc, Deerfield, IL.
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium, Isavuconazonium Sulfate
Generic Name: posaconazole
Brand name: Noxafil
Synonyms: Posaconazole (oral/injection), Posaconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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