Isavuconazonium Sulfate and Phenytoin Extended-Release Capsules
Determining the interaction of Isavuconazonium Sulfate and Phenytoin Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using isavuconazonium together with phenytoin is not recommended. Combining these medications can significantly reduce the blood levels of isavuconazole, the active component of isavuconazonium, which may make the medication less effective in treating your fungal infection. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of isavuconazole, which is primarily metabolized by CYP450 3A4 and 3A5 and subsequently by uridine diphosphate glucuronosyltransferases (UGT). When multiple doses of isavuconazonium sulfate (prodrug of isavuconazole) were administered to healthy volunteers with multiple doses of the potent CYP450 3A4 inducer rifampin (600 mg), mean isavuconazole peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 75% and 97%, respectively.
MANAGEMENT: Concomitant use of isavuconazonium sulfate with potent CYP450 3A4 inducers is considered contraindicated.
- "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc, Deerfield, IL.
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Isavuconazonium Sulfate-Phenytoin Infatabs
- Isavuconazonium Sulfate-Phenytoin injection
- Isavuconazonium Sulfate-Phenytoin Intravenous
- Isavuconazonium Sulfate-Phenytoin Oral Suspension
- Isavuconazonium Sulfate-Phenytoin Sodium
- Isavuconazonium Sulfate-Phenytoin Sodium, Prompt injection
- Phenytoin Extended-Release Capsules-Isavuconazonium Sulfate Capsules
- Phenytoin Extended-Release Capsules-Isavuconazonium Sulfate Injection
- Phenytoin Extended-Release Capsules-Isentress
- Phenytoin Extended-Release Capsules-Isentress (Raltegravir Chewable Tablets)
- Phenytoin Extended-Release Capsules-Isentress (Raltegravir Powder for Oral Suspension)
- Phenytoin Extended-Release Capsules-Isentress (Raltegravir Tablets)