Isavuconazonium Sulfate and Recombivax HB Adult

• Generic Name: isavuconazonium
• Dosage Forms: n.a.
• Other Brand Names: Cresemba

Treatment of invasive aspergillosis; designated an orphan drug by FDA for this indication.

IDSA considers IV voriconazole the drug of choice for primary treatment of invasive aspergillosis; amphotericin B and isavuconazonium recommended as alternatives for primary treatment. For salvage therapy in patients refractory to or intolerant of primary antifungal therapy, IDSA recommends IV amphotericin B, an IV echinocandin (caspofungin, micafungin), oral or IV posaconazole, or itraconazole oral suspension.

Mucormycosis

Treatment of invasive mucormycosis; designated an orphan drug by FDA for this indication.

Esophageal Candidiasis

Treatment of esophageal candidiasis.

Esophageal candidiasis requires treatment with a systemic antifungal (not a topical antifungal).

IDSA recommends oral fluconazole as the preferred drug of choice for treatment of esophageal candidiasis; if oral therapy not tolerated, IV fluconazole or an IV echinocandin (anidulafungin, caspofungin, micafungin) recommended.

For treatment of esophageal candidiasis in HIV-infected adults, CDC, NIH, and IDSA recommend oral or IV fluconazole or itraconazole oral solution. Oral or IV voriconazole, oral isavuconazonium, an IV echinocandin (anidulafungin, caspofungin, micafungin), or IV amphotericin B recommended as alternatives.

Candidemia and Other Invasive Candida Infections

Has been used for treatment of candidemia and other invasive infections caused by Candida; designated an orphan drug by FDA for treatment of invasive candidiasis/candidemia.

• Generic Name: hepatitis b adult vaccine
• Dosage Forms: n.a.
• Other Brand Names: Engerix-B, Heplisav-B, Recombivax HB Adult, Recombivax HB Dialysis Formulation

Hepatitis is a serious disease caused by a virus. Hepatitis causes inflammation of the liver, vomiting, and jaundice (yellowing of the skin or eyes). Hepatitis can lead to liver cancer, cirrhosis, or death.

Hepatitis B is a disease of the liver that is spread through blood or bodily fluids, sexual contact or sharing IV drug needles with an infected person, or during childbirth when the mother is infected.

The Recombivax HB Adult is used to help prevent this disease in adults.

This vaccine works by exposing you to a small amount of the virus, which causes the body to develop immunity to the disease. This vaccine will not treat an active infection that has already developed in the body.

Vaccination with Recombivax HB Adult is recommended for all adults who are at risk of getting hepatitis B. Risk factors include: having more than one sex partner; being a homosexual male; having sexual contact with infected people; having chronic liver disease; having diabetes and being under age 60; having HIV or AIDS; using intravenous (IV) drugs; being on dialysis or receiving blood transfusions; working in an institution for developmentally disabled patients; working in healthcare or public safety and being exposed to human blood; being in the military or traveling to high-risk areas; and living with a person who has hepatitis B.

Like any vaccine, the hepatitis B vaccine may not provide protection from disease in every person.