Isavuconazonium Sulfate Capsules and Sustiva

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using isavuconazonium together with efavirenz may decrease the blood levels and effects of both drugs. Using these medications together may cause isavuconazonium and efavirenz to be less effective. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications, or your doctor may prescribe alternative medications that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of efavirenz and isavuconazonium sulfate (prodrug of isavuconazole) may result in a reduction in the plasma concentrations and therapeutic effects of both drugs. The proposed mechanisms involve efavirenz induction of CYP450 3A4/5-mediated metabolism of isavuconazole and isavuconazole induction of CYP450 2B6-mediated metabolism of efavirenz. When multiple doses of isavuconazonium sulfate were administered to healthy volunteers with multiple doses of the potent CYP450 3A4 inducer rifampin (600 mg), mean isavuconazole peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 75% and 97%, respectively.

MANAGEMENT: Caution is advised during concomitant use of isavuconazonium sulfate with efavirenz. The potential for decreased efficacy of both drugs should be considered.

Isavuconazonium Sulfate Capsules

Generic Name: isavuconazonium

Brand name: Cresemba

Synonyms: Isavuconazonium, Isavuconazonium Sulfate

What is Isavuconazonium Sulfate Capsules?

Sustiva

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: n.a.

What is Sustiva?