Isentress HD and Rabeprazole Sprinkle Capsules
Determining the interaction of Isentress HD and Rabeprazole Sprinkle Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Since raltegravir solubility is increased at higher pH, coadministration with agents that elevate gastric pH may theoretically increase the plasma concentrations of raltegravir. However, concurrent use of proton pump inhibitors or H2-receptor antagonists in clinical trials did not result in meaningful differences in the safety of raltegravir. Based on these data, no dosage adjustment of raltegravir is necessary when used together with proton pump inhibitors or H2-receptor antagonists.
- "Product Information. Isentress (raltegravir)." Merck & Company Inc, West Point, PA.
Generic Name: raltegravir
Brand name: Isentress, Isentress HD
Synonyms: Isentress HD (Oral)
Generic Name: rabeprazole
Brand name: Aciphex, AcipHex Sprinkle
Synonyms: Rabeprazole, RABEprazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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