Isentress (Raltegravir Powder for Oral Suspension) and Zinc Gluconate Capsules and Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.ADJUST DOSING INTERVAL: Coadministration with supplements containing polyvalent cations such as zinc may decrease the plasma concentrations of integrase strand transfer inhibitors (INSTIs) such as elvitegravir and raltegravir. The mechanism involves chelation of the INSTI by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. The clinical relevance is unknown. MANAGEMENT: If concomitant use is required, monitor for virologic efficacy and administer the INSTI such as elvitegravir or raltegravir at least 2 hours before or 6 hours after supplements containing polyvalent cations such as zinc. References US National Library of Medicine "Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Available from: URL: https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/287/insti-drug-interactions." ([2019, Nov 6]):

ADJUST DOSING INTERVAL: Coadministration with supplements containing polyvalent cations such as zinc may decrease the plasma concentrations of integrase strand transfer inhibitors (INSTIs) such as elvitegravir and raltegravir. The mechanism involves chelation of the INSTI by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. The clinical relevance is unknown.

MANAGEMENT: If concomitant use is required, monitor for virologic efficacy and administer the INSTI such as elvitegravir or raltegravir at least 2 hours before or 6 hours after supplements containing polyvalent cations such as zinc.

Isentress (Raltegravir Powder for Oral Suspension)

Generic Name: raltegravir

Brand name: Isentress, Isentress HD

Synonyms: Isentress

What is Isentress (Raltegravir Powder for Oral Suspension)?

Zinc Gluconate Capsules and Tablets

Generic Name: zinc gluconate

Brand name: Orazinc, Orazinc 110

Synonyms: Zinc gluconate, Zinc Gluconate

What is Zinc Gluconate Capsules and Tablets?