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Ismelin and Zyvox (Linezolid Suspension)

Determining the interaction of Ismelin and Zyvox (Linezolid Suspension) and the possibility of their joint administration.

Check result:

Ismelin <> Zyvox (Linezolid Suspension)

Relevance: 24.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Linezolid may reduce the effectiveness of guanethidine in treating your high blood pressure. You should wait 7 to 14 days after you are off linezolid before you start using linezolid. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Theoretically, monoamine oxidase inhibitors (MAOIs) may antagonize the hypotensive effect of peripherally-acting antiadrenergic agents like guanadrel and guanethidine that work by depleting catecholamine stores from adrenergic nerve endings. MAOIs inhibit the breakdown of catecholamines and enhance storage in adrenergic neurons.

MANAGEMENT: While clinical data are lacking, guanadrel and guanethidine should preferably not be used with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). The manufacturer of phenelzine considers the combination contraindicated. At least 7 to 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with guanadrel or guanethidine. If they have been used together, clinicians should be aware that significant hypotension may occur following withdrawal of MAOI therapy.

References

Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31
Iversen LL "Inhibition of noradrenaline uptake by drugs." J Pharm Pharmacol 17 (1965): 62-4
Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36
Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7
De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5
"Product Information. Nardil (phenelzine)." Parke-Dvis, Morris Plains, NJ.
Lee CH, Strosberg AM, Warren LA "The importance of catecholamine uptake in the reversal of guenethidine blockade of adrenergic neurons." Res Commun Chem Pathol Pharmacol 30 (1980): 3-14
Gulati OD, Dave BT, Gokhale SD, Shah KM "Antagonism of adrenergic neuron blockade in hypertensive subjects." Clin Pharmacol Ther 7 (1966): 510-4

Ismelin

Generic Name: guanethidine

Brand name:

Synonyms: Ismelin (Oral)

What is Ismelin?

Zyvox (Linezolid Suspension)

Generic Name: linezolid

Brand name: Zyvox

Synonyms: Zyvox

What is Zyvox (Linezolid Suspension)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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