Isometheptene, Dichloralphenazone and Acetaminophen Capsules and Pitolisant
Determining the interaction of Isometheptene, Dichloralphenazone and Acetaminophen Capsules and Pitolisant and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with pitolisant may reduce plasma concentrations of substrates of CYP450 2C, P-glycoprotein (P-gp), and uridine diphosphate glucuronosyltransferases (UGTs). Based on in vitro data, pitolisant and its main metabolites may induce CYP450 2C, P-gp, and UGTs. Clinical data are not available. MANAGEMENT: Caution is recommended if pitolisant is used in combination with substrates of CYP450 2C, P-gp, and/or UGTs. Clinical and laboratory monitoring may be appropriate for some drugs whenever pitolisant is added to or withdrawn from therapy. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA.
Professional:MONITOR: Coadministration with pitolisant may reduce plasma concentrations of substrates of CYP450 2C, P-glycoprotein (P-gp), and uridine diphosphate glucuronosyltransferases (UGTs). Based on in vitro data, pitolisant and its main metabolites may induce CYP450 2C, P-gp, and UGTs. Clinical data are not available.
MANAGEMENT: Caution is recommended if pitolisant is used in combination with substrates of CYP450 2C, P-gp, and/or UGTs. Clinical and laboratory monitoring may be appropriate for some drugs whenever pitolisant is added to or withdrawn from therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA.
Generic Name: acetaminophen / dichloralphenazone / isometheptene mucate
Brand name: Nodolor
Synonyms: Acetaminophen, Isometheptene, and Dichloralphenazone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Isometheptene, Dichloralphenazone and Acetaminophen Capsules-Pitolisant Hydrochloride
- Isometheptene, Dichloralphenazone and Acetaminophen Capsules-Pitressin
- Isometheptene, Dichloralphenazone and Acetaminophen Capsules-Pitressin Injection
- Isometheptene, Dichloralphenazone and Acetaminophen Capsules-Pitressin Synthetic
- Isometheptene, Dichloralphenazone and Acetaminophen Capsules-Placidyl
- Isometheptene, Dichloralphenazone and Acetaminophen Capsules-Plan B
- Pitolisant-IsonaRif
- Pitolisant-Isoniazid
- Pitolisant-Isoniazid and rifampin
- Pitolisant-Isoniazid Injection
- Pitolisant-Isoniazid Oral Solution
- Pitolisant-Isoniazid Oral, Intramuscular