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Isoniazid Oral, Intramuscular and Xanax

Determining the interaction of Isoniazid Oral, Intramuscular and Xanax and the possibility of their joint administration.

Check result:

Isoniazid Oral, Intramuscular <> Xanax

Relevance: 11.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Isoniazid may increase the blood levels and effects of ALPRAZolam. This can increase the risk of side effects including excessive drowsiness and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Isoniazid may increase the pharmacologic effects of benzodiazepines by decreasing clearance and increasing half-life. The mechanism is related to the inhibition of CYP450 3A4 hepatic oxidative metabolism of benzodiazepines.

MANAGEMENT: Patients on concomitant therapy should be monitored for altered benzodiazepine effects. Dosage reductions may be appropriate if patients experience prolonged or excessive CNS-depressant effects.

References

Ochs HR, Greenblatt DJ, Knuchel M "Differential effect of isoniazid on triazolam oxidation and oxazepam conjugation." Br J Clin Pharmacol 16 (1983): 743-6
Ochs HR, Greenblatt DJ, Roberts GM, Dengler HJ "Diazepam interaction with antituberculosis drugs." Clin Pharmacol Ther 29 (1981): 671-8

Isoniazid Oral, Intramuscular

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: Isoniazid

What is Isoniazid Oral, Intramuscular?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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