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Isoniazid, pyrazinamide, and rifampin and Procardia XL

Determining the interaction of Isoniazid, pyrazinamide, and rifampin and Procardia XL and the possibility of their joint administration.

Check result:

Isoniazid, pyrazinamide, and rifampin <> Procardia XL

Relevance: 12.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

RifAMPin may significantly reduce the blood levels of NIFEdipine, which may make the medication ineffective or less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Potent inducers of CYP450 3A4 such as rifampin may significantly decrease the oral bioavailability of calcium channel blockers, the majority of which are primarily metabolized by the isoenzyme. Undetectable plasma levels have been reported for some calcium blockers when given orally.

MANAGEMENT: Concomitant use of oral calcium channel blockers with potent CYP450 3A4 inducers should generally be avoided. Some authorities consider the combination of nifedipine or nisoldipine with rifampin to be contraindicated.

References

Atmar RL, Greenberg SB, Quarles JM, et al. "Safety and pharmacokinetics of rimantadine small-particle aerosol." Antimicrob Agents Chemother 34 (1990): 2228-33
Tada Y, Tsuda Y, Takeshi O, et al. "Case report: nifedipine-rifampicin interaction attenuates the effect on blood pressure in a patient with essential hypertension." Am J Med Sci 303 (1992): 25-7
Holtbecker N, Fromm MF, Kroemer HK, Ohnhaus EE, Heidemann H "The nifedipine-rifampin interaction - evidence for induction of gut wall metabolism." Drug Metab Dispos 24 (1996): 1121-3
Tada Y, Tsuda Y, Otsuka T, et al "Case report: nifedipine-rifampicin interaction attenuates the effect on blood pressure in a patient with essential hypertension." Am J Med Sci 303 (1992): 25-7
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Tsuchihashi K, Fukami K, Kishimoto H, et al "A case of variant angina exacerbated by administration of rifampicin." Heart Vessels 3 (1987): 214-7

Isoniazid, pyrazinamide, and rifampin

Generic Name: isoniazid / pyrazinamide / rifampin

Brand name: Rifater

Synonyms: n.a.

What is Isoniazid, pyrazinamide, and rifampin?

Procardia XL

Generic Name: nifedipine

Brand name: Adalat CC, Procardia, Procardia XL, Afeditab CR, Nifediac CC, Nifedical XL, Adalat

Synonyms: n.a.

What is Procardia XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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