Isoniazid Solution and Parafon Forte DSC

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using chlorzoxazone together with isoniazid may increase the effects of chlorzoxazone. Contact your doctor if you experience headache, nausea, or drowsiness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: In one small study, patients receiving isoniazid were reported to have a 44% increased peak concentration of chlorzoxazone, 125% increased area under the plasma concentration-time curve, and 99% prolonged mean plasma elimination half-life. The oral clearance of chlorzoxazone was reported to have been reduced. Chlorzoxazone is a substrate of CYP2E1. Isoniazid is an inducer and inhibitor of CPY2E1.

MANAGEMENT: Caution is advised for increased levels of chlorzoxazone if these medications are to be used together. Dosage adjustments may be appropriate. Patients should be advised to notify their physician if they experience headache, nausea, or drowsiness.

Isoniazid Solution

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: Isoniazid

What is Isoniazid Solution?

Parafon Forte DSC

Generic Name: chlorzoxazone

Brand name: Lorzone, Parafon Forte DSC, Paraflex, Remular-S, Relaxazone, Eze DS, Remular, Strifon Fort

Synonyms: n.a.

What is Parafon Forte DSC?