Isoniazid Solution and Roflumilast
Determining the interaction of Isoniazid Solution and Roflumilast and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Isoniazid may increase the blood levels of roflumilast. You may be more likely to experience side effects of roflumilast such as diarrhea, nausea, abdominal pain, weight loss, headache, insomnia, depression, and anxiety. Let your doctor know if side effects become excessive or intolerable. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with CYP450 1A2 inhibitors or dual CYP450 1A2/3A4 inhibitors may increase the systemic exposure to roflumilast and its pharmacologically active N-oxide metabolite. In drug interaction studies, the total exposure to roflumilast and roflumilast N-oxide increased by 25%, 47% and 59% with the CYP450 1A2 inhibitor enoxacin and the dual CYP450 1A2/3A4 inhibitors cimetidine and fluvoxamine, respectively.
MANAGEMENT: Treatment with roflumilast should be re-evaluated if an interaction is suspected and persistent intolerability occurs. Patients should be advised to contact their physician if they experience increased frequency and/or severity of side effects such as diarrhea, nausea, abdominal pain, weight loss, and headache.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Daxas (roflumilast)." Nycomed Inc, Princeton, NJ.
- "Product Information. Daliresp (roflumilast)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: isoniazid
Brand name: Nydrazid
Synonyms: Isoniazid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Isoniazid Solution-Roflumilast Tablets
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- Isoniazid Solution-Rogaine (Minoxidil Topical Foam)
- Isoniazid Solution-Rogaine (Minoxidil Topical Solution)
- Isoniazid Solution-Rogaine Extra Strength Mens
- Isoniazid Solution-Rogaine For Men Extra Strength Topical
- Roflumilast-Isoniazid Syrup
- Roflumilast-Isoniazid Tablets
- Roflumilast-Isoniazid, pyrazinamide, and rifampin
- Roflumilast-Isoproterenol
- Roflumilast-Isoproterenol Hydrochloride
- Roflumilast-Isoproterenol Injection