Isoptin SR and Tipranavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using verapamil together with tipranavir may alter the effects of verapamil. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with tipranavir in combination with ritonavir may alter the pharmacokinetics of calcium channel blockers that are dual substrates of CYP450 3A4 and P-glycoprotein. The potential changes cannot be predicted due to the conflicting effects of tipranavir and ritonavir on CYP450 3A4 and P-glycoprotein. Specifically, ritonavir is a potent inhibitor of CYP450 3A4 and tend to reduce clearance of substrate drugs, while tipranavir is a potent inducer of P-glycoprotein intestinal efflux transporters and tend to increase clearance of substrate drugs.

MANAGEMENT: Caution is advised if calcium channel blockers such as diltiazem, felodipine, nicardipine, nisoldipine, and verapamil are coadministered with tipranavir/ritonavir. Patients should be monitored for potentially altered pharmacologic response to calcium channel blocker therapy following initiation or discontinuation of tipranavir/ritonavir.

Isoptin SR

Generic Name: verapamil

Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM

Synonyms: n.a.

What is Isoptin SR?

Tipranavir

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: n.a.

What is Tipranavir?