Isoptin SR and Tofranil injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before taking verapamil, tell your doctor if you also use imipramine. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase the effects of imipramine. You should notify your doctor if you have symptoms of dry mouth, blurry vision, irregular or fast heartbeat, constipation, urine retention, dizziness, or a drop in blood pressure that is brought on by changes in body position. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Concurrent administration of verapamil may increase tricyclic antidepressant (TCA) serum concentrations. The mechanism appears to be inhibition of CYP450 metabolism. Pharmacologic and toxic effects of TCAs may be increased.

MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever verapamil is added to or discontinued from an antidepressant regimen. Patients should be advised to notify their physician if they experience excessive antidepressant effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension. Dose adjustments may be necessary.

Isoptin SR

Generic Name: verapamil

Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM

Synonyms: n.a.

What is Isoptin SR?

Tofranil injection

Generic Name: imipramine

Brand name: Tofranil, Tofranil-PM

Synonyms: Tofranil

What is Tofranil injection?