Isosorbide Dinitrate and Hydralazine and Tolmetin Sodium
Determining the interaction of Isosorbide Dinitrate and Hydralazine and Tolmetin Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking hydrALAZINE, tell your doctor if you also use tolmetin. This combination may cause dizziness, headaches, or blurred vision. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of hydralazine and dihydralazine. This interaction suggests that prostaglandins play a pivotal role in the vasodilatory effects of hydralazine. However, data have been conflicting.
MANAGEMENT: Recommended management consists of monitoring the antihypertensive effectiveness of hydralazine or dihydralazine during therapy, increasing the dosage as necessary, or decreasing or substituting another drug for the NSAID.
- Cinquegrani MP, Liang CS "Indomethacin attenuates the hypotensive action of hydralazine." Clin Pharmacol Ther 39 (1986): 564-70
Generic Name: hydralazine / isosorbide dinitrate
Brand name: BiDil
Synonyms: Hydralazine and isosorbide dinitrate
Generic Name: tolmetin
Brand name: Tolectin, Tolectin DS, Tolectin 600
Synonyms: Tolmetin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Isosorbide Dinitrate and Hydralazine-Tolmetin Tablets
- Isosorbide Dinitrate and Hydralazine-Tolsura
- Isosorbide Dinitrate and Hydralazine-Tolterodine
- Isosorbide Dinitrate and Hydralazine-Tolterodine Extended-Release Capsules
- Isosorbide Dinitrate and Hydralazine-Tolterodine Tablets
- Isosorbide Dinitrate and Hydralazine-Tolterodine Tartrate
- Tolmetin Sodium-Isosorbide Dinitrate Extended-Release Capsules and Tablets
- Tolmetin Sodium-Isosorbide dinitrate Oral, Sublingual
- Tolmetin Sodium-Isosorbide Dinitrate Tablets
- Tolmetin Sodium-Isosorbide mononitrate
- Tolmetin Sodium-Isosorbide Mononitrate Extended Release
- Tolmetin Sodium-Isosorbide Mononitrate Extended-Release Tablets