Isosorbide Dinitrate and Hydralazine and Topcare Ibuprofen Drops
Determining the interaction of Isosorbide Dinitrate and Hydralazine and Topcare Ibuprofen Drops and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking hydrALAZINE, tell your doctor if you also use ibuprofen. This combination may cause dizziness, headaches, or blurred vision. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of hydralazine and dihydralazine. This interaction suggests that prostaglandins play a pivotal role in the vasodilatory effects of hydralazine. However, data have been conflicting.
MANAGEMENT: Recommended management consists of monitoring the antihypertensive effectiveness of hydralazine or dihydralazine during therapy, increasing the dosage as necessary, or decreasing or substituting another drug for the NSAID.
- Cinquegrani MP, Liang CS "Indomethacin attenuates the hypotensive action of hydralazine." Clin Pharmacol Ther 39 (1986): 564-70
Generic Name: hydralazine / isosorbide dinitrate
Brand name: BiDil
Synonyms: Hydralazine and isosorbide dinitrate
Generic Name: ibuprofen
Brand name: Advil, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Advil Liqui-Gels, Caldolor, NeoProfen, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength
Synonyms: Ibuprofen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Isosorbide Dinitrate and Hydralazine-Topcare Ibuprofen Junior Strength Chewable
- Isosorbide Dinitrate and Hydralazine-Topcare Ibuprofen Oral Suspension
- Isosorbide Dinitrate and Hydralazine-Topcare Ibuprofen PM
- Isosorbide Dinitrate and Hydralazine-Topcare Infants Ibuprofen
- Isosorbide Dinitrate and Hydralazine-Topcare Miconazole 3
- Isosorbide Dinitrate and Hydralazine-Topcare Miconazole 7
- Topcare Ibuprofen Drops-Isosorbide Dinitrate Extended-Release Capsules and Tablets
- Topcare Ibuprofen Drops-Isosorbide dinitrate Oral, Sublingual
- Topcare Ibuprofen Drops-Isosorbide Dinitrate Tablets
- Topcare Ibuprofen Drops-Isosorbide mononitrate
- Topcare Ibuprofen Drops-Isosorbide Mononitrate Extended Release
- Topcare Ibuprofen Drops-Isosorbide Mononitrate Extended-Release Tablets