Isosorbide dinitrate Oral, Sublingual and Rosiglitazone and metformin
Determining the interaction of Isosorbide dinitrate Oral, Sublingual and Rosiglitazone and metformin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using rosiglitazone together with isosorbide dinitrate. Combining these medications may increase the risk of chest pain and heart problems. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you experience symptoms of chest pain or tightness in your chest. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The concomitant use of rosiglitazone with nitrates may increase the risk of myocardial ischemia. Results of clinical trials have suggested that rosiglitazone is associated with a higher risk of angina or myocardial infarction. In patients also taking nitrates, the risk was increased by 12 events per 100 patient years. However, long term trials have not been conducted.
MANAGEMENT: The concomitant use of rosiglitazone and nitrates should generally be avoided.
- "Product Information. Avandia (rosiglitazone)" SmithKline Beecham, Philadelphia, PA.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Generic Name: isosorbide dinitrate
Brand name: Dilatrate-SR, Isochron, Isordil, Sorbitrate, Isordil Titradose, ISDN, Isordil Tembids
Synonyms: Isosorbide dinitrate, Isosorbide Dinitrate
Generic Name: metformin / rosiglitazone
Brand name: Avandamet
Synonyms: Rosiglitazone and metformin (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Isosorbide dinitrate Oral, Sublingual-Rosiglitazone Maleate
- Isosorbide dinitrate Oral, Sublingual-Rosula
- Isosorbide dinitrate Oral, Sublingual-Rosula Cleansing Cloth
- Isosorbide dinitrate Oral, Sublingual-Rosula Wash
- Isosorbide dinitrate Oral, Sublingual-Rosuvastatin
- Isosorbide dinitrate Oral, Sublingual-Rosuvastatin Calcium
- Rosiglitazone and metformin-Isosorbide Dinitrate Tablets
- Rosiglitazone and metformin-Isosorbide mononitrate
- Rosiglitazone and metformin-Isosorbide Mononitrate Extended Release
- Rosiglitazone and metformin-Isosorbide Mononitrate Extended-Release Tablets
- Rosiglitazone and metformin-Isosorbide Mononitrate Tablets
- Rosiglitazone and metformin-Isotretinoin