Isotretinoin Capsules and Sustiva

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Efavirenz may reduce the blood levels and effects of ISOtretinoin. Contact your doctor if your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. In addition, each of these medications can affect the liver, and taking them together may increase the risk of liver damage. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with efavirenz may decrease the plasma concentrations of retinoids that are substrates of the CYP450 3A4 isoenzyme such as alitretinoin, bexarotene, isotretinoin, and tretinoin. The mechanism is accelerated clearance due to induction of CYP450 3A4 activity by efavirenz.

MONITOR: Coadministration of efavirenz with other agents known to induce hepatotoxicity, including retinoids, may potentiate the risk of liver injury. Efavirenz has been associated with hepatotoxicity during postmarketing use. Among reported cases of hepatic failure, a few occurred in patients with no preexisting hepatic disease or other identifiable risk factors. Retinoids have been associated with hepatotoxicity ranging from transient and reversible increases in liver transaminases to clinical jaundice, hepatitis, and cirrhosis.

MANAGEMENT: Caution is advised if efavirenz must be used concomitantly with retinoids that undergo metabolism by CYP450 3A4. Pharmacologic response to the retinoid should be monitored more closely whenever efavirenz is added to or withdrawn from therapy, and the retinoid dosage adjusted as necessary. The risk of hepatic injury should also be considered during treatment with this combination. Patients should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, light-coloured stools, and jaundice. Monitoring of liver function tests should occur before and during treatment, especially in patients with underlying hepatic disease (including hepatitis B or C coinfection) or marked transaminase elevations. The benefit of continued therapy with efavirenz and/or the retinoid should be considered against the unknown risks of significant liver toxicity in patients who develop persistent elevations of serum transaminases greater than five times the upper limit of normal.

Isotretinoin Capsules

Generic Name: isotretinoin

Brand name: Absorica, Amnesteem, Claravis, Myorisan, Sotret, Zenatane, Accutane

Synonyms: Isotretinoin, ISOtretinoin (Systemic)

What is Isotretinoin Capsules?

Sustiva

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: n.a.

What is Sustiva?