Istradefylline and Lanoxin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration of istradefylline may increase the serum concentrations of digoxin. The proposed mechanism is istradefylline inhibition of the P-glycoprotein-mediated renal tubular secretion of digoxin. When a single dose of digoxin (0.4 mg) was administered with istradefylline (40 mg daily for 21 days), the peak plasma concentration (Cmax) and total systemic exposure (AUC(inf)) of digoxin was increased by 33% and 21%, respectively, when compared with digoxin alone. MANAGEMENT: Serum digoxin levels and pharmacologic effects should be closely monitored following the addition or withdrawal of istradefylline, and the digoxin dosage adjusted as needed. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat. References "Product Information. Nourianz (istradefylline)." Kyowa Kirin, Inc, Bedminster, NJ.

MONITOR: Coadministration of istradefylline may increase the serum concentrations of digoxin. The proposed mechanism is istradefylline inhibition of the P-glycoprotein-mediated renal tubular secretion of digoxin. When a single dose of digoxin (0.4 mg) was administered with istradefylline (40 mg daily for 21 days), the peak plasma concentration (Cmax) and total systemic exposure (AUC(inf)) of digoxin was increased by 33% and 21%, respectively, when compared with digoxin alone.

MANAGEMENT: Serum digoxin levels and pharmacologic effects should be closely monitored following the addition or withdrawal of istradefylline, and the digoxin dosage adjusted as needed. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Istradefylline

Generic Name: istradefylline

Brand name: Nourianz

Synonyms: n.a.

What is Istradefylline?

Lanoxin

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: n.a.

What is Lanoxin?