Itraconazole Capsules (Tolsura) and Rosuvastatin Calcium
Determining the interaction of Itraconazole Capsules (Tolsura) and Rosuvastatin Calcium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with itraconazole may slightly increase the plasma concentrations of rosuvastatin. The mechanism of interaction has not been described. According to the product labeling for rosuvastatin, itraconazole (200 mg once a day for 5 days) increased the area under the plasma concentration-time curve (AUC) of a 10 mg and 80 mg dose of rosuvastatin by 39% and 28%, respectively. These increases are not considered clinically significant.
- "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc, Mississauga, ON.
- Holtzman CW, Wiggins BS, Spinler SA "Role of P-glycoprotein in statin drug interactions." Pharmacotherapy 26 (2006): 1601-7
Generic Name: itraconazole
Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura
Synonyms: Itraconazole
Generic Name: rosuvastatin
Brand name: Crestor, Ezallor Sprinkle
Synonyms: Rosuvastatin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Itraconazole Capsules (Tolsura)-Rotavirus Oral Vaccine
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- Rosuvastatin Calcium-Itraconazole Oral Solution
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- Rosuvastatin Calcium-Ivabradine
- Rosuvastatin Calcium-Ivabradine Hydrochloride
- Rosuvastatin Calcium-Ivabradine Oral Solution
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