Ivacaftor and lumacaftor and Zantac (Ranitidine Syrup)
Determining the interaction of Ivacaftor and lumacaftor and Zantac (Ranitidine Syrup) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Lumacaftor may alter the blood levels and effects of raNITIdine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro data demonstrating both inhibition and induction of P-glycoprotein (P-gp) efflux transporter, lumacaftor has the potential to alter the plasma concentrations of drugs that are substrates of P-gp. Additionally, a clinical study with ivacaftor monotherapy showed that ivacaftor is a weak inhibitor of P-gp. Therefore, concomitant use of lumacaftor/ivacaftor with P-gp substrates may alter the systemic exposure to these substrates.
MANAGEMENT: Caution is advised when lumacaftor is used concurrently with medications that are substrates of the P-glycoprotein efflux transporter, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever lumacaftor is added to or withdrawn from therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
Generic Name: ivacaftor / lumacaftor
Brand name: Orkambi
Synonyms: Lumacaftor and Ivacaftor
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Zantac
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ivacaftor and lumacaftor-Zantac (Ranitidine Tablets and Capsules)
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- Ivacaftor and lumacaftor-Zarah
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