Ivacaftor Granules and Phenytoin Intravenous
Determining the interaction of Ivacaftor Granules and Phenytoin Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ivacaftor together with phenytoin is generally not recommended. Combining these medications may significantly decrease the blood levels of ivacaftor, which may make the medication less effective in the treatment of cystic fibrosis. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of ivacaftor, which is primarily metabolized by the isoenzyme. In study subjects, administration of a single 150 mg dose of ivacaftor with the potent CYP450 3A4 inducer rifampin (600 mg once daily) decreased ivacaftor peak plasma concentration (Cmax) and systemic exposure (AUC) by 80% and 89%, respectively, compared to administration of ivacaftor alone. When lumacaftor/ivacaftor was coadministered with rifampin, lumacaftor pharmacokinetics were minimally affected, but ivacaftor Cmax and AUC decreased by an average of 50% and 57%, respectively. No pharmacokinetic data are available for elexacaftor or tezacaftor, but decreased exposures are expected according to prescribing information.
MANAGEMENT: Concomitant use of ivacaftor-containing medications with potent CYP450 3A4 inducers is not recommended.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Symdeko 4-Week (ivacaftor-tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: ivacaftor
Brand name: Kalydeco
Synonyms: Ivacaftor
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin (Intravenous)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ivacaftor Granules-Phenytoin Oral Suspension
- Ivacaftor Granules-Phenytoin Sodium
- Ivacaftor Granules-Phenytoin Sodium, Prompt injection
- Ivacaftor Granules-Phenytoin Suspension
- Ivacaftor Granules-Philith
- Ivacaftor Granules-Phillips Milk of Magnesia
- Phenytoin Intravenous-Ivacaftor Tablets
- Phenytoin Intravenous-Ivermectin
- Phenytoin Intravenous-Ivermectin (Systemic)
- Phenytoin Intravenous-Ivermectin Cream
- Phenytoin Intravenous-Ivermectin Lotion
- Phenytoin Intravenous-Ivermectin Tablets