Ivacaftor Tablets and Poly-Tussin EX Syrup
Determining the interaction of Ivacaftor Tablets and Poly-Tussin EX Syrup and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ivacaftor may increase the blood levels and effects of dihydrocodeine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ivacaftor may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme and/or P-glycoprotein (P-gp) efflux transporter. The mechanism is decreased clearance via these pathways due to inhibition by ivacaftor and its pharmacologically active M1 metabolite. The interaction has been studied with midazolam and digoxin, probe substrates for CYP450 3A4 ad P-gp, respectively. In study subjects, midazolam systemic exposure (AUC) increased by 1.5-fold when it was administered with ivacaftor, suggesting weak inhibition of CYP450 3A4 by ivacaftor. Likewise, digoxin AUC increased by 1.3-fold with ivacaftor, which is also consistent with weak inhibition of P-gp by ivacaftor.
MANAGEMENT: Caution is advised when ivacaftor is used with drugs that are substrates of CYP450 3A4 and/or P-gp, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ivacaftor is added to or withdrawn from therapy.
- "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
Generic Name: ivacaftor
Brand name: Kalydeco
Synonyms: Ivacaftor
Generic Name: dihydrocodeine / guaifenesin / phenylephrine
Brand name:
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ivacaftor Tablets-Poly-Tussin HD
- Ivacaftor Tablets-Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Liquid)
- Ivacaftor Tablets-Poly-Vent DM (Guaifenesin, Pseudoephedrine, and Dextromethorphan Tablets and Capsules)
- Ivacaftor Tablets-Poly-Vent IR
- Ivacaftor Tablets-Poly-Vi-Flor
- Ivacaftor Tablets-Poly-Vi-Flor (Pediatric Multivitamin Chewables with Fluoride and Iron)
- Poly-Tussin EX Syrup-Ivermectin
- Poly-Tussin EX Syrup-Ivermectin (Systemic)
- Poly-Tussin EX Syrup-Ivermectin Cream
- Poly-Tussin EX Syrup-Ivermectin Lotion
- Poly-Tussin EX Syrup-Ivermectin Tablets
- Poly-Tussin EX Syrup-Ivermectin topical