Ivacaftor Tablets and Simvastatin Tablets
Determining the interaction of Ivacaftor Tablets and Simvastatin Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ivacaftor may increase the blood levels and effects of simvastatin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with ivacaftor may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme and/or P-glycoprotein (P-gp) efflux transporter. The mechanism is decreased clearance via these pathways due to inhibition by ivacaftor and its pharmacologically active M1 metabolite. The interaction has been studied with midazolam and digoxin, probe substrates for CYP450 3A4 ad P-gp, respectively. In study subjects, midazolam systemic exposure (AUC) increased by 1.5-fold when it was administered with ivacaftor, suggesting weak inhibition of CYP450 3A4 by ivacaftor. Likewise, digoxin AUC increased by 1.3-fold with ivacaftor, which is also consistent with weak inhibition of P-gp by ivacaftor.
MANAGEMENT: Caution is advised when ivacaftor is used with drugs that are substrates of CYP450 3A4 and/or P-gp, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ivacaftor is added to or withdrawn from therapy.
- "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
Generic Name: ivacaftor
Brand name: Kalydeco
Synonyms: Ivacaftor
Generic Name: simvastatin
Brand name: Zocor, Flolipid
Synonyms: Simvastatin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ivacaftor Tablets-Sinarest
- Ivacaftor Tablets-Sinarest Nasal
- Ivacaftor Tablets-Sinarest Sinus
- Ivacaftor Tablets-Sine-Off Maximum Strength
- Ivacaftor Tablets-Sinelee
- Ivacaftor Tablets-Sinelee Patch
- Simvastatin Tablets-Ivermectin
- Simvastatin Tablets-Ivermectin (Systemic)
- Simvastatin Tablets-Ivermectin Cream
- Simvastatin Tablets-Ivermectin Lotion
- Simvastatin Tablets-Ivermectin Tablets
- Simvastatin Tablets-Ivermectin topical