Ivosidenib and Methergine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4. MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects. References "Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.

GENERALLY AVOID: Coadministration with ivosidenib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. No pharmacokinetic data are available; however, ivosidenib induces its own metabolism via CYP450 3A4.

MANAGEMENT: Concomitant use of ivosidenib and sensitive CYP450 3A4 substrates or substrates with narrow therapeutic ranges should generally be avoided. If coadministration is required, patients should be monitored carefully for potential loss of therapeutic effects.

Ivosidenib

Generic Name: ivosidenib

Brand name: Tibsovo

Synonyms: n.a.

What is Ivosidenib?

Methergine

Generic Name: methylergonovine

Brand name: Methergine

Synonyms: Methergine (oral and injection)

What is Methergine?