Ivosidenib and Onasemnogene Abeparvovec

• Generic Name: ivosidenib
• Dosage Forms: n.a.
• Other Brand Names: Tibsovo

Ivosidenib targets a specific gene mutation called IDH1, which can affect your bone marrow. IDH1 mutation prevents young blood cells from developing into healthy adult blood cells, which can result in symptoms of acute myeloid leukemia (AML).

Ivosidenib is used to treat AML in adults with an IDH1 mutation. Your doctor will test you for this gene. Ivosidenib is used when other treatments did not work or have stopped working.

Ivosidenib is also used in adults 75 years and older who have newly-diagnosed AML and cannot use certain chemotherapy treatments because of other health problems.

Ivosidenib may also be used for purposes not listed in this medication guide.

• Generic Name: onasemnogene abeparvovec
• Dosage Forms: n.a.
• Other Brand Names: Zolgensma, Zolgensma

Onasemnogene abeparvovec is used to treat spinal muscular atrophy in children younger than 2 years old who have a specific gene mutation that affects nerve signals to the muscles.

onasemnogene abeparvovec may not be effective in a child who is completely paralyzed or is dependent on a ventilator for breathing.

Onasemnogene abeparvovec may also be used for purposes not listed in this medication guide.