Ixazomib Citrate and Phenytoin Oral Suspension
Determining the interaction of Ixazomib Citrate and Phenytoin Oral Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenytoin may significantly reduce the blood levels of ixazomib, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of ixazomib, which is a substrate of the isoenzyme. When ixazomib was administered with the potent CYP450 3A4 inducer rifampin, ixazomib peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 54% and 74%, respectively. The therapeutic efficacy of ixazomib may be reduced.
MANAGEMENT: Concomitant use of ixazomib with potent CYP450 3A4 inducers should generally be avoided.
- "Product Information. Ninlaro (ixazomib)." Takeda Pharmaceuticals America, Lincolnshire, IL.
Generic Name: ixazomib
Brand name: Ninlaro
Synonyms: Ixazomib
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ixazomib Citrate-Phenytoin Sodium
- Ixazomib Citrate-Phenytoin Sodium, Prompt injection
- Ixazomib Citrate-Phenytoin Suspension
- Ixazomib Citrate-Philith
- Ixazomib Citrate-Phillips Milk of Magnesia
- Ixazomib Citrate-Phisohex
- Phenytoin Oral Suspension-Ixekizumab
- Phenytoin Oral Suspension-Ixekizumab Auto-Injectors
- Phenytoin Oral Suspension-Ixekizumab Prefilled Syringes
- Phenytoin Oral Suspension-Ixekizumab Subcutaneous
- Phenytoin Oral Suspension-Ixempra
- Phenytoin Oral Suspension-Ixempra Kit