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Jantoven and LiQsorb coenzyme Q-10

Determining the interaction of Jantoven and LiQsorb coenzyme Q-10 and the possibility of their joint administration.

Check result:

Jantoven <> LiQsorb coenzyme Q-10

Relevance: 22.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using warfarin together with ubiquinone. This combination may reduce the effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to testing your prothrombin time or International Normalized Ratio (INR). It is important to tell your healthcare provider about all other medications you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

GENERALLY AVOID: Coadministration with coenzyme Q10 (also known as ubiquinone or ubidecarenone) may reduce the hypoprothrombinemic effect of warfarin and other oral anticoagulants. The exact mechanism of interaction is unknown, although coenzyme Q10 is structurally related to menaquinone (vitamin K2) and may have procoagulant effects. There have been reports of decreased warfarin response in patients using coenzyme Q10 and a return to normal anticoagulation following its discontinuation. In contrast, a study consisting of 24 patients stabilized on warfarin for at least several months found no significant effect of coenzyme Q10 on INR or warfarin dosage compared to placebo, and no thromboembolic events were observed in the study. However, it is important to recognize that pharmacologic effects of herbal products may be highly variable due to inconsistencies in formulation and potency of commercial preparations.

MANAGEMENT: In general, patients should consult a healthcare provider before taking any herbal or alternative medicine. Given the potential for interaction and the narrow therapeutic index of oral anticoagulants, these drugs should preferably not be used with coenzyme Q10. If they are given together, the INR must be checked frequently and anticoagulant dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of coenzyme Q10 in patients who are stabilized on their anticoagulant regimen.

References

"Product Information. Coumadin (warfarin)." DuPont Pharmaceuticals, Wilmington, DE.
Engelsen J, Nielsen JD, Winther K "Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial." Thromb Haemost 87 (2002): 1075-6
Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7; quiz 1228-30
Spigset O "Reduced effect of warfarin caused by ubidecarenone." Lancet 344 (1994): 1372-3

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?

LiQsorb coenzyme Q-10

Generic Name: ubiquinone

Brand name: Coenzyme Q10, CoQ10, elppa CoQ10, LiQsorb, Q-Sorb Co Q-10, QuinZyme, Co-Q10, NutraDrops, Liquid Co-Q10, Co Q-10, Coenzyme Q10, LiQ-10

Synonyms: LiQsorb (coenzyme Q-10)

What is LiQsorb coenzyme Q-10?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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